By Alessio Fasano, Dr. Alessio Fasano MD
A scientific advisor to Gluten-Related problems presents fundamental healthiness care prone the succinct fabric they should instantly assessment and help their sufferers. Gluten-related issues have a large presentation, and this article covers the popularity, review, and multi-disciplinary method of the administration of affliction. Readers will enjoy the common review of gluten intolerance and from the common experience method of constructing therapy and nutritional plans. scientific vignettes provide clinicians real-life situations to aid placed the illness and its therapy in context for his or her patients. �Read more...
summary: A medical advisor to Gluten-Related problems presents fundamental healthiness care prone the succinct fabric they should instantly evaluation and help their sufferers. Gluten-related issues have a large presentation, and this article covers the popularity, review, and multi-disciplinary method of the administration of sickness. Readers will enjoy the normal review of gluten intolerance and from the commonsense method of constructing therapy and nutritional plans. scientific vignettes supply clinicians real-life eventualities to assist positioned the affliction and its remedy in context for his or her sufferers
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Additional info for A Clinical Guide to Gluten-Related Disorders
68 Further studies using combined genomic approaches are needed to clarify the role of the microbiome in CD. The effect of timing of gluten introduction on risk of CD became apparent with the Swedish celiac “epidemic” in the 1980s to 1990s. 69,70 This rapid rise and decline in disease incidence correlated with the changes in infant feeding practices, including younger age of gluten introduction, increased amount of gluten in diet, and reduced breast-feeding. However, the reasons why early gluten introduction causes higher risk of CD remains largely unexplained.
31. Myleus A, Stenlund H, Hernell O, et al. Early vaccinations are not risk factors for celiac disease. Pediatrics. 2012;130:e63–e70. 32. Ploski R, Ek J, Thorsby E, et al. On the HLA-DQ(alpha 1*0501, beta 1*0201)-associated susceptibility in celiac disease: A possible gene dosage effect of DQB1*0201. Tissue Antigens. 1993;41:173–177. 33. van Belzen MJ, Koeleman BP, Crusius JB, et al. Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients. Genes Immun. 2004;5:215–220.
91 Those molecules can act as ligands for NK-like receptors present of IELs contributing to their killing ability. IL-15 is a key innate immune cytokine overexpressed in both epithelium and lamina propria of CD patients. 99,100 Furthermore, IL-15 contributes to promote the CD4+ T cell adaptive response. As we already discussed, both the responses are required to obtain a full activation of IELs and thus villous atrophy; moreover, the epithelial stress and the adaptive response are likely to influence each other.
A Clinical Guide to Gluten-Related Disorders by Alessio Fasano, Dr. Alessio Fasano MD