By Jonathan I. Epstein
- Side-by-side comparisons for every significant differential diagnoses for speedy and exact reference
- Over 1,450 colour images that depict the positive aspects of every entity and canopy all significant differential diagnoses in genitourinary pathology
- A functional guide that directs all textual content and images towards differentiating among entities to make sure the pathologist arrives at a correct diagnosis
- A significant other site with fully-searchable textual content and a picture bank
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Additional resources for Differential Diagnoses in Surgical Pathology: Genitourinary System
11 Hormone-treated prostate cancer with pyknotic hyperchromatic nuclei and abundant xanthomatous cytoplasm. 10 High-grade foamy gland adenocarcinoma. 12 Adenocarcinoma of the prostate with hormone therapy affect with small nuclei, xanthomatous cytoplasm, and clear cleft-like spaces lined by pyknotic tumor nuclei resembling lymphocytes. 15 Basal Cell Hyperplasia with Nucleoli vs. High-Grade Prostatic Intraepithelial Neoplasia Basal Cell Hyperplasia with Nucleoli High-Grade Prostatic Intraepithelial Neoplasia Age Typically, adults seen on needle biopsy, TURP, or radical prostatectomy Typically adults Location Transition > peripheral zone Peripheral = transition zone Symptoms Asymptomatic Typically asymptomatic Signs None Usually incidentally detected on biopsy performed for elevated serum PSA levels Etiology Usually nonspecific and focal.
3). 6 Extensive signet-ring cell–like change in adenocarcinoma with hyperchromatic nuclei. 8 Reactive Noncribriform Prostate Glands vs. Prostatic Adenocarcinoma with Inflammation Reactive Noncribriform Prostate Glands Prostatic Adenocarcinoma with Inflammation Age Any age Typically 50 to elderly, although not rare in 40s Location Peripheral = transition zone Peripheral > transition zone Symptoms Typically asymptomatic Typically asymptomatic. 6) Histology 1. Reactive glands can be increased in number and crowded, mimicking cancer 1.
May show enlarged nuclei and prominent nucleoli, sometimes accompanied by mitotic figures. May see more prominent nucleoli than PAH (Fig. 11) 6. Cords of adenocarcinoma composed of short single row of cells typically with enlarged nuclei, abundant cytoplasm, and visible nucleoli 7. May be intimately associated with less atrophic carcinoma (Fig. 12) •• AMACR usually negative •• Basal cell markers entirely negative in the atypical atrophic glands (Fig. 10). 10 Post–atrophic Hyperplasia of the Prostate (PAH) vs.
Differential Diagnoses in Surgical Pathology: Genitourinary System by Jonathan I. Epstein